ATCC  

ATCC has the world’s largest and most extensive product catalog of human and animal cell lines for research purposes. The cell biology collection includes more than 5,000 continuous cell lines available by species, tissue/disease types, and molecular signatures.  ATCC offers convenient and affordable Cell Authentication testing kits for Human STR, Mouse STR and Mycoplasma detection. Human STR testing allows one to establish a DNA fingerprint or confirm your cell line identity. Mouse STR assay validates the authenticity of mouse cell lines and detects contamination by human and African green monkey DNA. To help you detect or rule out mycoplasma contamination of your cell cultures quickly, ATCC offers two different mycoplasma testing services to choose from: PCR-based mycoplasma testing, which is rapid and sensitive, and culture-based mycoplasma testing, which is also sensitive and includes both direct and indirect culture methods that are based on the Food and Drug Administration's Points to Consider in the Characterization of Cell Lines Used to Produce Biologicals.

Your research depends on reliable biomaterials that you can trust. That means ensuring that the quality and authenticity of your material remains consistent throughout each stage of your project. With nearly a century of experience in biomaterials services and management, we have the expertise needed to authenticate, store, maintain, and globally distribute biological samples. By entrusting ATCC with your samples, you can rest assured that your materials are securely managed through a temperature-controlled supply chain, and 24/7 equipment monitoring. We’ll take care of the logistics and resources, so you can focus on what’s important—your research. Some things to consider about biomaterials storage services: Would you rather spend your budget on securing your cells or on infrastructure and people to develop more drugs? Would you rather ship the materials yourself or outsource the process to a trusted partner?  By trusting ATCC, you can avoid time and labor intensive in-house measures and eliminate associated risks and costs. Our longevity in the industry and reputation for stringent quality controls gives you the confidence that your drug development efforts will be fully supported.

ATCC genetically modified human primary cells so they exhibit the growth characteristics of a continuous cell line with extended proliferative capacity yet maintain the physiology of a primary cell. ATCC cells, media, and reagents allow you to investigate renal, neural, airway, and skin toxicity for such applications as high-content screening, 3-D culture, spheroid culture, permeability assays, metabolic stability and survival studies, transport activity measurement, and more.

ATCC hTERT-immortalized primary cells include:

Aortic endothelial cells

Barrett’s esophageal epithelial cells

Bronchial epithelial cells

Respiratory epithelial cells

Chrondrocyte fibroblast cells

Dermal microvascular endothelial cells (including TIME cells)

Dermal melanocytes

Endometrial fibroblast cells

Foreskin keratinocytes

Lung endothelial cells

Mammary epithelial cells

Mesenchymal stem cells

NTAP Schwann cells

Pancreas duct cells

Prostrate cells

Renal epithelial cells

Retinal pigmented epithelial cells

Skin fibroblast cells

Neural progenitor cells (NPCs) are potent models of normal and disease neurobiology and cell-based neurological therapy development and testing. NPC solutions from ATCC are a complete system for investigating development, degeneration and regeneration, neurogenetics, neural excitability, nervous system disorders, neurotransmitters, and screening therapeutics. We offer normal and Parkinson’s disease iPSC-derived NPCs. Additionally, we offer gene-edited, lineage specific reporter NPCs. ATCC NPCs are derived from a collection of well characterized, integration-free reprogrammed iPSCs. The single donor state of the parental line ensures reduced variation between experiments. Other advantages of ATCC authenticated NPCs include, easy endpoint readout, >80% post-thaw cell viability and post-thaw cell viability >1x106/vial. The cells also exhibit longevity >15 PDLs or 5 passages. The marker expression is Nestin and Pax 6 positive, Tra-I-60 negative. The cells are sterility tested and are negative for bacteria, yeast, fungi, mycoplasma with no viruses detected. The neuronal differentiation potential is >70% Tuj1+ early neurons and >10% dopaminergic neurons.

As scientists, we are challenged to identify the adverse effects of a broad range of substances to protect people and the environment. It is critical that the standards and model organisms used in toxicological testing are reliable and authenticated. ATCC provides primary cell cultures that toxicologists need to perform standardized, reliable, and reproducible toxicology studies. Primary cultures are cells freshly isolated from organ tissue and maintained for growth in vitro. Epithelial cells, fibroblasts, keratinocytes, melanocytes, endothelial cells, muscle cells, hematopoietic cells, and mesenchymal stem cells are the cell types most frequently used in research. Human primary cells are commonly used in vitro for preclinical and investigative biological research, such as studies of intercellular and intracellular communication, developmental biology, and the mechanisms seen in cancer, Parkinson’s disease, and diabetes. Human primary cells derived from particular tissues and maintained with the appropriate primary cell culture media and supplements now represent a more advanced model for recapitulating that tissue cell type.