ACIC Machinery / PBL S.r.l.

Coral Springs,  FL 
United States
  • Booth: 8023

We deliver turnkey equipment and automation solutions for radiopharmaceutical and bio/pharmaceutical manufacturing.

At ACIC Machinery, we deliver turnkey equipment and automation solutions for bio/pharmaceutical and radio-pharmaceutical manufacturing. We have extensive experience designing, building and commissioning both standard and custom projects.

Shielded hot cells with integrated robots or telemanipulators for the formulation, dispensing and inspection, packaging of nuclear/radio-pharmaceutical products.

Our global clients range in size from medium laboratories to large multinational pharmaceutical corporations.

Brands: ACIC Pharmaceutical Machinery| P.B.L. Srl (


N-R&D (Nuclear Formulation and Dispensing Hot Cell) 1
N-R&D (Nuclear Formulation and Dispensing Hot Cell) 2
N-R&D (Nuclear Formulation and Dispensing Hot Cell) 3
N-R&D (Nuclear Formulation and Dispensing Hot Cell) 4

 Press Releases

  • New inspection machine for RTF container

    We are thrilled to announce the launch of our cutting-edge robotic visual inspection machine for Ready-To-Use (RTU) containers. This state-of-the-art system employs advanced camera technology and Artificial Intelligence (AI) to deliver precise inspections for particulate matter and cosmetic defects.

    With a fully automatic format changeover and a compact, flexible design, the machine is capable of handling a wide range of containers with ease.

    Thanks to its sophisticated AI technology, our RTF ROBOX A/I guarantees unparalleled accuracy when it comes to detecting particle and cosmetic defects. As a result, the machine is able to overcome previous challenges such as air bubbles, silk-screening, and external defects that were previously difficult to detect.

    The RTF ROBOX A/I boasts a variety of features, including liquid particle control, LYO cosmetic control, cosmetic checks, vacuum decay, and high voltage methods, as well as integrated labeling heads and a user-friendly interface. The machine can inspect different types of containers – such as vials, syringes, and cartridges – with varying sizes and shapes, and has a speed range of 6 to 20 BpM.

    Main Features:

    • Manual or automatic container loading system
    • Robotic container handling system
    • 8 inspection stations (standard version)
    • Ability to vary the number of inspection stations to meet your specific needs
    • Manual or automatic camera system
  • What is artificial intelligence?

     Artificial intelligence (AI) involves using computers and software to do things that would traditionally require human intelligence. The difference? AI can consume and process large amounts of data. Levels of data and information that humans simply cannot process.

     The goals of AI technology and AI-supported machines are to:

    • Recognize patterns
    • Make decisions
    • Make judgments

     That mimics, and ultimately supersedes human behavior and intelligence.

     ACIC Machinery is proud to offer inspection machinery solutions for pharmaceutical products that are fully automated and supported by AI technology.

    AI-supported inspection machines quickly spot and identify problems in any part of the production line monitored by state-of-the-art cameras. Studies suggest that AI-supported solutions can increase defect detection rates by up to 90% compared to human inspection rates (Dorfman, 2022).

     Powered by AI, our automated inspection machinery greatly enhance the speed and accuracy of container inspection, as well as substantially reduce rates of false positives.

    So how does it work?

     The first level of the inspection system is comprised of standard inspection software, which mainly detects moving particles but can also detect some non-moving particles.

    The second level of the inspection system is comprised of AI software which has two main functions:

    1. Reduce false positives by distinguishing between real particles and false particles (eg. Bubbles)

    2. Capability to add new types of particles to the AI database for inspection. The AI database generates a new knowledge base when it undergoes training for new defects by qualified personnel. Previous versions of the knowledge base are stored and archived. Only qualified personnel can access training mode in the system.

    Contact us at ACIC Pharmaceutical Machinery to learn more about our AI-supported inspection equipment.  Let’s start designing an inspection system for your manufacturing facility that will increase the speed, accuracy, and performance of your operations.

    Learn more about our automatic inspection machines: 


    1. Our partners

    2. Dorfman, E. (2022, April 19). How AI for Quality Control Enhances Yield in Manufacturing. Retrieved from

  • In recent years, there have been major advances in automation equipment for the manufacture of radiopharmaceuticals.

    Creating modern facilities that incorporate automated manufacturing processes improves product consistency, quality, and operator safety.

    Many radiopharmaceuticals are produced under aseptic conditions to ensure they meet all purity and quality standards. There can be multiple manual processes in the manufacturing of sterile drugs, and each manual process during the aseptic assembly has the potential to introduce contamination. In addition to product safety, operator safety can be improved when introducing automation by reducing radiation exposure to personnel.

    Automation in Hot Cells
    Most operations in the hot cell are accomplished by using manipulators and robotic arms. Robotic arms can be programmed to automate processes inside and outside the hot cell including the opening of lead pots, the handling of lead pots and vials, automatic filling, and automatic visual inspection of labeling and cartoning. These automated processes can increase production speed, product quality, and reduce radiation exposure to operators.

    ACIC Pharmaceutical Machinery and our partners have extensive experience in the design and commissioning of state-of-the-art equipment and turnkey solutions for the manufacture of radiopharmaceuticals.

    If you have any questions regarding automation in radiopharmaceutical manufacturing, please contact us or read more on our radiopharmaceutical equipment.

    1. FDA. Sterile Drug Products Produced by Aseptic Processing — Current Good Manufacturing Practice. September 2004.
    2. IAEA. Radioisotope Handling Facilities and Automation of Radioisotope Production. December 2004.
    3. U.S. Pharmacopeia. <1015> Automated Radiochemical Synthesis Apparatus. USP 32, NF 27, 2009.
    4. Our Partners.

  • Radiofrequency Welding

    Radiofrequency (RF) welding, also known as high-frequency welding, is an effective sealing process for the manufacture of medical bags such as ostomy bags, urine bags, and blood bags.

    Radiofrequency welding works through the simultaneous application of a pressure force and an electromagnetic field with a frequency of either 27.12, 13.56, or 40.68 MHz on materials (for example, two films of PVC), which causes the material to melt, and the molecules to bond. This process makes the material weldable at relatively modest temperatures (for example, 30˚C) and results in a robust seal that is leak-proof and consistent.

    Why use RF Welding?

    RF welding results in a strong, leak-proof bond without the use of additional materials such as adhesives. The welds are durable, consistent, and ensures the integrity of the bag, which is crucial for pharmaceutical products. RF welding optimizes energy consumption, does not generate fumes, and does not require the use of additives. These aspects are beneficial for both operators and environmental protection.

    RF Welding can be performed on materials including polyvinylchloride (PVC), polyurethanes, polyethylene terephthalate (PET), and acrylonitrile butadiene styrene (ABS).

    Thermocontact Welding

    Thermocontact welding uses external heat and pressure to bond materials. Thermocontact welding can be a good alternative when materials are not suitable for RF welding. Materials for thermocontact welding include polypropylene (PP), polyethylene (PE), and PVC-free plastics.

  • Automation in radiopharmaceutical manufacturing is a great thing for all stages of the supply chain. In the manufacturing of radiopharmaceuticals, for example, the automation process can prevent accidents caused by human error. But leakage of contaminants still happens due to various factors that can exist in the process. Precautions can be taken that will help control or mitigate radioactive leakage that can occur.

    1. Safe Surfaces
    Machinery with areas that materials can easily get caught and exist, such as trims and corners, for example, increase the occurrence of radioactive contamination. The materials forming the surface of machinery, and the casing for the machinery should be easy to decontaminate. During design, non-porous, corrosion-resistant materials should be specified. For example, the use of rounded edges enables the user to easily wash away contaminants from spaces where they might normally get stuck.

    2. Air Filtering
    Radioactive particles in the air quickly spread through a building, unless precautions are taken. Be proactive by preventing particles from accumulating in the first place. Taking steps to maintain extreme cleanliness at all time, filtering the air, and setting up the ventilation system so that air from a controlled area is not re-circulated back into the building, are all proactive measures that will ensure only the cleanest environment. Integrating HEPA filtration systems contributes to a controlled ISO Class 5 environment.

    3. Disposal of Waste
    When there is contamination, and it has been dealt with, the radioactive waste (say, from decontaminating a room) needs to be disposed of safely. This will necessarily involve transporting the waste away from where it is. So, when planning an automated environment, think about the path that this waste will travel when leaving the building and ensure that it will not spread contaminants further during the disposal.

    4. Double Containment
    Double containment should be used as a fail-safe in case the first line of defense fails. Be sure to plan for larger problems that involve more than a single machine or area. Consider the spread of contamination in the event of a large accident – don’t just think about the machine and its immediate vicinity, but about where radioactive contaminants might spread through contact, waste disposal, or airflow. For example, if the container around the machine is negative pressure, and springs a leak, radioactive particles in the air will not spread. So far so good, but if there is a larger accident, this may not be enough, and contaminants will spread from the room throughout the building. By making the entire room negative pressure, you can contain more serious leaks with relative ease.

    In the manufacturing process that involves radioactive elements, a thorough consideration beyond the obvious decontamination plan and process is not just smart but should be mandatory. Steps can be taken in stages, such as in the design of the hot-cell automation process. Early design considerations will not just save time and money, but will also create a safer environment and a more efficient way of dealing with potential harm.

    If you have any questions regarding automation in radiopharmaceutical manufacturing, please contact us.

  • ACIC Machinery is a leading provider of filling and sealing solutions ranging from small and large volume parenteral products to sterile and non-sterile filling. Applications include ampoules, vials, syringes, cartridges, glass/plastic bottles, and soft bags. These machines can process liquid, semi-solid, and powder products (freeze-dried). Let’s take a closer look at a few of our machines:


    Filling & Closing Machine for Nested Containers

    The filling and closing machines have been specifically designed to process pre-sterilized nested containers such as syringes and cartridges. Despite its compact design, it can accommodate different filling systems to treat liquid, freeze-dried, suspension, emulsion, and oil-based products.

    nested containers

    Vial Filling Machine for Aseptic Processing

    This machine is used for the filling, stoppering, and sealing operations of injectables in glass vials for aseptic conditions. These machines are suitable for both liquid and freeze-dried products.

    vial filling

    Closing & Sealing Machines for Bottles & Vials

    Fully automatic closing/capping and sealing machines are designed for the application of different closures on glass and plastic vials and bottles.

    vial filling

    Filling & Closing Machines for Pharmaceutical Processing

    Filling and closing machines are specifically designed for filling, plugging, and capping both sterile and non-sterile products such as syrup, ophthalmic solution, and nasal spray in either glass or plastic containers.

    Bottles and Spray


    ISBM (Injection, Stretch, Blow, Molding) Filling Line

    ISBM technology is the modern manufacturing trend for IV solutions and irrigation products. Complete processing lines for polypropylene (PP) bottles forming, filling, and closing starting from the raw PP granules.

    Injection Stretch Blow Molding

    Filling machine for pharmaceutical bags

    Filling and closing machines are made to treat IV bags. These machines can fill a single chamber bag as well as a dialysis multi-chamber bag. The machine design allows a high level of flexibility in means of productivity and bag shapes.

    Bag Filling

    Our Solution

    ACIC Machinery brings you many solutions for your pharmaceutical filling and sealing needs.

  • Fast Turnaround for 7m2 and 30m2 Freeze Dryers

    These two freeze dryers were meticulously engineered to adhere to FDA 21 CFR Part 11 and cGMP standards for both pilot and commercial batch production. As of now, the 7m2 unit is 70% mechanically complete, while the 30m unit is 40% mechanically complete.

    Since the freeze dryers are not yet fully completed, this presents an opportune moment to incorporate any necessary adjustments to suit your specific requirements. We are receptive to discussing your production needs in order to customize the machine to your satisfaction.

    In collaboration with our clients, we maintain a close working relationship with our research, validation, and production teams to ensure optimal machine layout and processes that fulfill all customer specifications.

    Prior to equipment installation, our state-of-the-art research facility conducts pilot tests to validate the theoretical conditions of our clients’ processes. This meticulous process is carried out to guarantee optimal outcomes from each and every freeze dryer we produce.

    Simply reach out to us at 1.833.ACICMAC (1.833.227.2622) or contact us here,  and we’ll gladly discuss with you how our freeze dryers can be tailored to your specific requirements, provide you with additional information about our fast delivery models, and guide you through the purchasing process. We are committed to providing you with the best price and service possible, and our team is enthusiastic about assisting you in any way we can.


  • RTF-FILL 200 (F/C Machine for RTF Containers)
    A Monoblock machine that performs filing and closing processes for syringes, cartridges, and vials in Nest-Tub and/or Nest-Trays

  • Introducing our cutting-edge filling and closing solution - the automatic RTF Fill machine for syringes, cartridges and vials in Nest-Tub and/or Nest-Trays.                                                                                                                 

    With the ability to handle container sizes ranging from 0.5 ml to 50 ml, our system offers unparalleled versatility. The compact design and user-friendly interface make operation a breeze.

    What sets our machine apart is its clever design and meticulous material research, ensuring optimal performance and easy cleaning even when handling aggressive products. The RTF Fill machine guarantees efficiency and reliability, making it the ideal choice for all your vial filling and closing needs.

  • V-Fill SVP (F/S/S Machine for SVP Products)
    A monoblock equipment custom designed to perform filling, stoppering, aluminum capping/flip-off sealing under isolator. Dedicated sensors monitor 100% of the production....

  • Our company specializes in creating personalized automatic filling machines for SVP (small volume parenteral) products, capable of filling, stoppering, and sealing glass vials ranging from 2R to 100R in size. Our machines are specifically designed to handle both standard and cytotoxic products. We take pride in our clever machine design and use of carefully selected materials, ensuring optimal performance and ease of cleaning, even with aggressive products such as hydrogen peroxide (H2O2). We conduct extensive research to ensure that our machines are not only efficient but also reliable.

    Main features

    Stand-alone or in-line version
    ⦁ Camera control for vial flange inspection
    ⦁ Camera control for vial bottom inspection
    ⦁ Filling system with peristaltic pump (disposable) or piston filler

    ⦁ Integrated load cell system (IPC)
    ⦁ Oxygen sensor at the machine exit
    ⦁ Pressure cap insertion unit
    ⦁ Aluminium cap sealing unit
    ⦁ Isolator or Laminar Air Flow integrated on the machine structure
    ⦁ User-friendly machine interface

    Machine Output

    50 to 200 BpM

  • RTF Line (Nest/Trays) (Line for RTF Containers)
    A complete robotic line composed of washing machine, depyrogenation tunnel and final assembler for final sterile container packaging...

  • The production line is composed of three stations, namely the washing machine, depyrogenation tunnel, and tray loading system. These stations are seamlessly integrated to achieve optimal productivity. To ensure that the containers are free from cosmetic defects, particles, and contamination, there is no glass-to-glass contact during the entire process. This results in fewer rejects and increased production efficiency. The production process employs cutting-edge equipment, and the facility is certified with ISO 7 and ISO 5 standards. The processes undergo constant monitoring and control to ensure that they are validated and compliant with the required standards.

    Hydro main features

    ⦁ Robotic loading/unloading
    ⦁ Washing and drying stations
    ⦁ Compact wet chamber
    ⦁ Fast change format

    ⦁ Siliconization cycle
    ⦁ Different monitoring functions
    ⦁ Customized transportation system
    ⦁ User-friendly and fast tool-free format change
    ⦁ Designed as a modular machine

    DTM main features

    ⦁ Depyrogenation Tunnel
    ⦁ Inlet chamber
    ⦁ Hot chamber
    ⦁ Cooling chamber

    ⦁ 6 Log reduction
    ⦁ User-friendly and fast tool-free format change
    ⦁ Designed as a modular machine

    Assembler main features

    ⦁ Capping/alu process
    ⦁ Siliconization process
    ⦁ Control of stopper/alu position
    ⦁ Control of correct silicon application

    ⦁ Syringes and Cartridge TUB and NEST preparation
    ⦁ Vials Trays
    ⦁ Container Nesting
    ⦁ Control of complete and conforming nest
    ⦁ Tyvek position and sealing
    ⦁ Sterile bag bagging
    ⦁ User-friendly and fast tool-free format change
    ⦁ Designed as a modular machine

    Machine Output

    100 to 400 BpM

  • D-FILL 150(Line for Unstable Diagnostic Container)
    A customized line with unscramble, filling and closing, labeling, and cartoning machine...

  • We custom designed, built, and successfully commissioned a complete line for diagnostic and chemical products that are contained in unstable plastic containers. The line comprises three stations, namely the filling system, ultrasonic welding, and cartoning system, all seamlessly integrated for optimal productivity. The line was specifically designed to address the high level of customization required to meet the client's needs, taking into account the container's high level of instability. Our cutting-edge equipment is used in each production process, and the facility is certified with ISO 7 and ISO 5 standards. The processes undergo regular monitoring and control to ensure compliance with the necessary standards.

    Main features

    ⦁  Customize loading/unloading system
    ⦁  IPC control (100% or statistical)
    ⦁  CIP/SIP system
    ⦁  Different filling options available

    ⦁  Different container closure systems available
    ⦁  Different monitoring functions (eg. monitoring of fill volume, seal integrity, etc)
    ⦁  User-friendly and fast tool-free format change
    ⦁  Designed as a modular machine
    ⦁  Custom-designed system
    ⦁  High flexibility for carton and box handling

    Machine Output

    20 to 400 BpM

  • N R&D(Nuclear Formulation and Dispensing Hot Cell)
    Shielded research & development (R&D) hot cell for formulating and dispensing nuclear medicine into glass vials...

  • We provide tailor-made formulation and dispensing hot cells specifically designed for nuclear medicine. Our in-line production process involves product formulation, filling, closing, and numerous quality controls, all of which are integrated into a lead-shielded system. This ensures that our clients receive top-of-the-line equipment, resulting in reduced product rejects and optimal production performance. We employ state-of-the-art equipment for every stage of the production process, while adhering to ISO 7 and ISO 5 certifications, and using validated processes that are closely monitored and controlled.

    Main Features

    •  Manual formulation HOT CELL
    •  Telemanipulator unit
    • Activity safe cart
    • Automatic dispensing HOT CELL
    • Customized dispensing unit
    • Linear waste bunker
    • IPC (100% In-Process Control) with retroactive feedback to the dosing system
    • Dose calibrator integrated
    • Sample drawer
    • Shielded cart
    • User-friendly and fast tool-free format change
    • Lead shielded from 10mm to 200 mm (equivalent lead glass)

    Machine Output

    2 to 20 BpM

  • N-FILL (Nuclear Vials Dispensing Unit)
    Compact stand-alone dispensing unit for nuclear medicine (AI)...

  • A stand-alone dispensing unit for nuclear medicine that can be easily installed in either new or existing hot cells. The compact design of this unit is ideal for space-constrained environments. The dispensing unit's use of state-of-the-art equipment in each stage of the production process ensures optimal performance and reduces the number of rejections. Our facility is certified with ISO 7 and ISO 5 standards, and the processes are validated, constantly monitored, and controlled to ensure compliance with the required standards.

    Main features

    ⦁ Customized dispensing unit
    ⦁ IPC (100% In-Process Control) with retroactive feedback to the dosing system
    ⦁ User-friendly and fast tool-free format change
    ⦁ Compact footprint

    Machine Output

    2 to 20 BpM